Figure 2: TLR2 activation induces mitochondrial dysfunction in RASFC in vitro. | Scientific Reports

Figure 2: TLR2 activation induces mitochondrial dysfunction in RASFC in vitro.

From: Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

Figure 2

(a) Representative bar graphs demonstrating the effects of Pam3CSK4 (1 μg/ml) stimulation (24 hrs) on reactive oxygen species (ROS), (b) mitochondrial membrane potential (MMP), (c) 4-hydroxynonenal (4-HNE) and (d) mitochondrial mass (all n = 8). (e) Representative bar graphs demonstrating IL-6, IL-8, RANTES and MCP-1 secretion from RASFC following Pam3CSK4 (1 μg/ml) stimulation in the presence or absence of ROS scavenger MitoTEMPO (10 μM) (24 hrs) (n = 5). Data was analysed using Wilcoxin Signed Rank test and is represented as Mean ± SEM, *p < 0.05, **p < 0.01 significantly different to control.

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