Figure 3: The RA synovium is more metabolically active than OA in vivo. | Scientific Reports

Figure 3: The RA synovium is more metabolically active than OA in vivo.

From: Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

Figure 3

(a) Representative photomicrographs demonstrating PKM2, Glut1 and GAPDH expression in RA (n = 25) and OA (n = 12) synovium. Mag10X for PKM2, Glut1, GAPDH. Scale bars in the bottom right hang corner represent 100 μm. (b) Representative bar graphs demonstrating semi-quantification of immunohistochemical staining of glycolytic markers PKM2, Glut1 and GAPDH in RA (n = 25) and OA (n = 12) lining, sublining and vasculature layers of synovial tissue. Data was analysed using Mann Whitney test and is represented as Mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.005 significantly different to control.

Back to article page