Figure 3: N296H-MAPT and MAPT-H1 transgenic mice do not display somatodendritic accumulation of tau. | Scientific Reports

Figure 3: N296H-MAPT and MAPT-H1 transgenic mice do not display somatodendritic accumulation of tau.

From: Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy

Figure 3

Coronal sections of 3–5 and 18–21 month old animals were stained with human-specific HT7 antibody to assess the formation of somatodendritic tau inclusions at a young (3–5 months) and old (18–21 months) age. No age-related changes in staining or evidence of tau inclusion formation were found in cortex (a) or hippocampus (b) of wild-type (H1) and N296H mutant (N51) animals in comparison to their non-transgenic tau knockout (KO) littermates. (c) Coronal sections of 18–21 month old animals were stained with the phospho-tau antibody AT8. Both H1 wild-type and N51 mutant tau expressing lines showed no accumulation of AT8 phospho-tau compared to the knockout negative control or the P301S mutant positive control. Positive control sections (pos ctrl, obtained from P301S transgenic animal) showing heavy HT7 and AT8 staining confirm the detection of somatodendritic tau inclusions. Scale bars = 100 μm.

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