Figure 2 | Scientific Reports

Figure 2

From: Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody

Figure 2

(A) Top six INSIP-specific autoantibodies identified in protein arrays. Distributions of normalized values across all arrays are shown. IPF, n = 10; INSIP, n = 8. Abbreviations: GARS, glycyl-tRNA synthetase; LOXL2, lysyl oxidase–like 2; PEX2, peroxisomal biogenesis factor 2; HK1, hexokinase 1; NINJ2, ninjurin 2; MX1, myxovirus resistance protein 1. (B) Lysates from HEK293 cells overexpressing FLAG-tagged MX1 were immunoprecipitated using sera from patients with INSIP, patients with IPF, or healthy control (HC) subjects. (C) Immunohistochemical analysis of MX1 in the lungs of control individuals (i,ii), patients with IPF (iii,iv), and patients with INSIP (v,vi). Scale bars denote 200 μm.

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