Table 3 Enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway associations (p ≤ 0.05) for proteins with enhanced antigenicity associated with IPF, INSIP, aPAP, or sarcoidosis cohorts (as listed in Supplementary Table S1).
Enriched KEGG pathway | KEGG pathway ID | p-value | Associated genes |
|---|---|---|---|
IPF | |||
Epstein-Barr virus infection | hsa05169 | 3.59367E-05 | PLCG2, POLR2L, POLR3K, YWHAZ |
RNA polymerase | hsa03020 | 0.000637682 | POLR2L, POLR3K |
Cytosolic DNA-sensing pathway | hsa04623 | 0.002387945 | POLR2L, POLR3K |
Pyrimidine metabolism | hsa00240 | 0.006154429 | POLR2L, POLR3K |
Purine metabolism | hsa00230 | 0.015536822 | POLR2L, POLR3K |
Metabolic pathways | hsa01100 | 0.027910673 | PHGDH, PLCG2, POLR2L, POLR3K |
Glycine, serine and threonine metabolism | hsa00260 | 0.044458806 | PHGDH |
INSIP | |||
Type II diabetes mellitus | hsa04930 | 0.000873218 | HK1, MAPK10, PRKCZ |
Aminoacyl-tRNA biosynthesis | hsa00970 | 0.001926137 | GARS, MARS, QARS |
Selenocompound metabolism | hsa00450 | 0.002240339 | MARS, PAPSS2 |
2-Oxocarboxylic acid metabolism | hsa01210 | 0.002240339 | ACO2, GPT2 |
Biosynthesis of amino acids | hsa01230 | 0.002571216 | ACO2, GPT2, SHMT2 |
Glyoxylate and dicarboxylate metabolism | hsa00630 | 0.004431551 | ACO2, SHMT2 |
Insulin signaling pathway | hsa04910 | 0.017360641 | HK1, MAPK10, PRKCZ |
Amino sugar and nucleotide sugar metabolism | hsa00520 | 0.017708207 | CYB5R1, HK1 |
Lysine biosynthesis | hsa00300 | 0.019434624 | ACO2 |
Butirosin and neomycin biosynthesis | hsa00524 | 0.024127735 | HK1 |
Influenza A | hsa05164 | 0.033284871 | MAPK10, MX1, RSAD2 |
Cyanoamino acid metabolism | hsa00460 | 0.033322731 | SHMT2 |
Adipocytokine signaling pathway | hsa04920 | 0.033887009 | MAPK10, RXRA |
Progesterone-mediated oocyte maturation | hsa04914 | 0.049314314 | CDK1, MAPK10 |
aPAP | |||
Nicotinate and nicotinamide metabolism | hsa00760 | 0.007881076 | NMRK1, QPRT |
Toxoplasmosis | hsa05145 | 0.01706976 | IL10RB, PIK3R5, TAB1 |
Cytokine-cytokine receptor interaction | hsa04060 | 0.027595171 | BMPR2, CSF2, CXCL12, IL10RB |
Jak-STAT signaling pathway | hsa04630 | 0.03365456 | CSF2, IL10RB, PIK3R5 |
Shigellosis | hsa05131 | 0.034504413 | HCLS1, UBE2D2 |
Fc epsilon RI signaling pathway | hsa04664 | 0.04433339 | CSF2, PIK3R5 |
Influenza A | hsa05164 | 0.045730626 | OAS1, PIK3R5, PLG |
Sarcoidosis | |||
Oocyte meiosis | hsa04114 | 0.019485662 | MAD2L1, SGOL1 |
PI3K–Akt signaling pathway | hsa04151 | 0.025741505 | PPP2R3B, RPS6K2, VWF |
