Figure 6: IHC analyses of surgically induced and ageing-associated OA. | Scientific Reports

Figure 6: IHC analyses of surgically induced and ageing-associated OA.

From: AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

Figure 6

(a,c and e) Representative IHC images of MMP-3, MMP-13 and phospho-NF-κB p65 in the medial tibial plateau in AMPKα1α2 conditional double knockout (AMPKα cDKO) mice and their WT littermates 2 weeks post-sham operation and DMM surgery or in mice at 9 months of age. Scale bars = 20 μm. The cellularity of the section was confirmed with haematoxylin staining. (b,d,f) Quantifications of the percentages of MMP-3, MMP-13 and phospho-NF-κB p65 are presented as percentages relative to cells stained for haematoxylin. (n = 6/group) MMP-3 = matrix metalloproteinase-3; MMP-13 = matrix metalloproteinase-13. *p < 0.05. **p < 0.01. ***p < 0.001. NS = not significant.

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