Figure 8: Intermittent fasting attenuates enhanced ROS levels and increased apoptotic cell death in UVRAG-deficient mice treated by DOX.
From: UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity
(a) Intermittent fasting rescued enhanced ROS levels in LVs from UVRAG-deficient mice measured 5 days after acute DOX treatment. n = 3 mice for each group. (b) Intermittent fasting attenuated increased apoptotic cell death in the hearts from UVRAG-deficient mice assessed 5 days after acute DOX treatment. n = 3 mice for each group. (c) Intermittent fasting rescued enhanced ROS levels in LVs from UVRAG-deficient mice at 4 weeks of DOX treatment in chronic DOX cardiotoxicity. n = 3 mice for each group. (d) Intermittent fasting attenuated increased apoptotic cell death in the hearts from UVRAG-deficient mice at 4 weeks of DOX treatment in chronic cardiotoxicity. n = 3 mice for each group. *P < 0.05 vs. WT + DOX + Fed, #P < 0.05 vs. UVRAG−/− + DOX + Fed, §P < 0.05 vs. WT + DOX + Fasted.
