Table 3 ROC analysis for differentiating the patients from the controls.

From: Family-based case-control study of homotopic connectivity in first-episode, drug-naive schizophrenia at rest

Brain regions

Area Under the Curve

Cut-off point

Sensitivity

Specificity

Differentiating the patients from the FBC

 Precuneus

0.805

0.8236 a

64.29% (18/28)

85.71% (24/28)

 Fusiform gyrus/cerebellum lobule VI

0.818

0.5866

82.14% (23/28)

75.00% (21/28)

 Lingual gyrus/cerebellum lobule VI

0.849

0.6917

92.86% (26/28)

64.29% (18/28)

Differentiating the patients from the HC

 Precuneus

0.851

0.9241

92.86% (26/28)

70.00% (28/40)

  1. aBy this cut-off point, the VMHC value of the precuneus could correctly classify 18 of 28 patients and 24 of 28 FBC, resulted in a sensitivity of 64.29% and a specificity of 85.71%. The meanings of other cut-off points were similar.
  2. ROC = receiver operating characteristic curves; FBC = family-based controls; HC = healthy controls; VMHC = voxel-mirrored homotopic connectivity.
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