Figure 4: Female mice display mild hypothyroidism.
From: Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function
(a) Thyroid morphology of representative 3-month old Rtfc+/+, Rtfc+/− and Rtfc−/− male and female mice. White and yellow arrows indicate the upper and lower edges of thyroid, respectively. Scale bars: 1 mm. (b) HE staining of thyroid tissue sections of 3-month old Rtfc+/+, Rtfc+/− and Rtfc−/− male and female mice. Scale bars: 200 μm. (c) Serum total T3, total T4 and TSH levels of 3-month old Rtfc+/+, Rtfc+/− and Rtfc−/− male and female mice, measured by radioimmunoassay. Each dot represents the value in a mouse, and bars are averages. (d) Expression of Tg and Tpo in the thyroid of 3-month old Rtfc+/+ and Rtfc−/− male and female mice. Each dot represents the value in a mouse, and bars are averages.
