Figure 1: p53 was induced in UUO mice.
From: p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO
The left ureter of male C57 mice was ligated for 0–7 days. (A) Immunoblot analysis of p53 and cyclophilin B (loading control) from mice kidneys of UUO groups at indicated time points. (B) Densitometric analyses were performed from each group (n = 8). (C) Immunohistochemical staining of p53 in kidney cortical tissues of sham and UUO mice at 7 days. (D) Representative quantification of p53 staining. Data were expressed as means ± sd (n = 8). Black arrows indicated the positive immunohistochemical staining of p53; #p < 0.05: day 3 or day 7 vs day 0; *p < 0.05: day 7 vs day 3. Original magnification, x200.
