Figure 2: Pifithrin-α attenuated renal fibrosis and apoptosis in UUO mice.
From: p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO
Male C57 mice after UUO were injected with 3 mg/kg pifithrin-α for 7 days. As controls, mice of the sham group were injected with saline. Renal cortical tissues were collected for hematoxylin and eosin staining to examine histology (A), Masson staining for fibrosis analysis (B), and for TUNEL assay of apoptosis (C). Tubulointerstitial fibrosis (D) and apoptosis (E) in the kidney cortex were quantified. Data were expressed as means ± sd (n = 8); #p < 0.05: the UUO group vs the sham group; *p < 0.05: the PIF group vs the UUO group. Original magnification, x200 or 400.
