Figure 3: Pifithrin-α inhibited the expression of fibronectin, collagen I, and α-SMA by blocking STAT3 signaling in UUO mice.
From: p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO
Male C57 mice after UUO were injected with 3 mg/kg pifithrin-a for 7 days. As controls, mice of the sham group were injected with saline. Renal cortical tissues were collected for immunohistochemistry staining to examine the expression of fibronectin, collagen I and α-SMA (A) and quantify immunohistochemistry staining (B). Data were expressed as means ± sd (n = 8); The black arrows indicated the positive immunohistochemical staining of fibronectin, collagen I, and α-SMA. #p < 0.05: the UUO group vs the sham group; *p < 0.05: the PIF group vs the UUO group. Original magnification, x200.
