Table 1 Descriptive statistics for the study population.

From: Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL

 

HC

RRMS

Prog MS

N

89

36

25

Age

42.0 ± 1.5

42.0 ± 1.7

51.7 ± 1.7**, ††

Male gender, %

38 (43%)

10 (28%)

11 (44%)

BMI

24.9 ± 0.4

25.9 ± 0.7

24.5 ± 0.9

Conventional lipid panel

 Total cholesterol, mg/dl

182.7 ± 3.8

169.6 ± 5.3

187.4 ± 7.9

 Triglycerides, mg/dl

113.6 ± 6.1

136.6 ± 17.8

106.2 ± 5.6

 HDL-c, mg/dl

61.0 ± 1.7

59.3 ± 2.3

60.8 ± 3.5

 LDL-c, mg/dl

109.8 ± 3.8

96.6 ± 4.8

115.6 ± 6.3

Lipoprotein subclasses

HDL

 Size nm

9.5 ± 0.1

9.4 ± 0.1

9.5 ± 0.1

 Total particle count, μmol/L

35.8 ± 0.6

36.3 ± 0.9

34.2 ± 1.1

 Small particle count, μmol/L

14.9 ± 0.9

15.2 ± 1.4

15.7 ± 1.2

 Medium particle count, μmol/L

12.1 ± 0.8

12.8 ± 1.3

9.0 ± 1.3

 Large particle count, μmol/L

7.5 ± 0.4

7.1 ± 0.5

8.1 ± 0.7

LDL

 Size, nm

21.0 ± 0.1

20.6 ± 0.1*, ‡

21.0 ± 0.1

 Total particle count, nmol/L

1, 182 ± 44.9

1, 099 ± 60.4

1, 217 ± 67.2

 Small particle count, nmol/L

463.9 ± 34.8

517.0 ± 62.7

418.2 ± 69.5

 Large particle count, nmol/L

432.9 ± 24.3

312.1 ± 39.8*, ‡‡

503.7 ± 51.4

IDL

 Particle count, nmol/L

166.7 ± 11.9

157.1 ± 18.1

170.6 ± 24.8

VLDL

 Size, nm

51.5 ± 0.8

53.6 ± 1.6

50.78 ± 1.2

 Total particle count, nmol/L

43.9 ± 2.8

48.9 ± 4.4

41.2 ± 3.5

 Small particle count, nmol/L

22.3 ± 1.5

24.9 ± 2.4

22.9 ± 2.5

 Medium particle count, nmol/L

17.6 ± 1.8

17.6 ± 2.2

15.3 ± 1.7

 Large particle count, nmol/L

5.0 ± 0.5

7.3 ± 1.7

4.2 ± 0.7

 VLDL-Triglycerides, mg/dl

78.7 ± 5.2

100.6 ± 15.3

70.8 ± 5.2

LP-IR index (0–100)

45.9 ± 2.5

50.9 ± 3.5

41.2 ± 3.8

  1. Values are means ± SEM. HC = healthy controls; RRMS = relapsing-remitting MS; Prog MS = progressive MS. * versus controls (*P < 0.05, **P < 0.01); †† versus RRMS (††P < 0.01), ‡‡versus progressive MS (‡‡P < 0.01).
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