Figure 7: XMJ recouples eNOS and inhibits oxidative stress in atherosclerotic rats. | Scientific Reports

Figure 7: XMJ recouples eNOS and inhibits oxidative stress in atherosclerotic rats.

From: Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo

Figure 7

The protocol of animal experiment was described in Fig. 6A. Carotid artery was subjected to assess the levels of (A) BH4 by HPLC and (B) p-eNOS by IHC. Blood was collected to assay (C) serum NO level by Griess method. (D) Distributions of eNOS dimer and monomer were determined by cold western blot analysis. a, Sham; b, Sham + XMJ-6.0; c, Atherosclerosis (AS); d, AS + XMJ-0.6; e, AS + XMJ-2.0; f, AS + XMJ-6.0; g, Lovastatin; h, ZBT. All data were expressed as mean ± SEM. 10–15 rats per group. *P < 0.05 VS Control, #P < 0.05 VS AS alone. (E) Proposed mechanism of XMJ against atherosclerosis.

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