Figure 4: The interaction map of proteins ≤25 kDa (Supplementary S2) obtained by STRING Bioinformatic analysis.

Colored network nodes represent query proteins, only the connected nodes are shown, red color indicates extracellular region proteins. Edges represent protein-protein interactions and include different type of actions depicted by the colored lines. For known interactions: pink, experimentally determined; turquoise, from curated databases. For predicted interactions: green, gene neighborhood; blue, gene co-occurrence. For others interactions: olive green, text mining; black, co-expression; purple, protein homology.