Table 2 Cox proportional hazards regression with competing risk of death for renal function recovery within 6 months after acute tubular necrosis.

From: Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease

Parameter variable

Renal function recovery a within 6 months

Model 1 adjusted for age and sex

Model 2 adjusted for statistically significant covariates in Table 1

Model 3 adjusted for age, sex and other variables b

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Tubular PRX3 high expression

15.45 (2.18–109.23)

0.006

8.74 (1.22–62.47)

0.03

8.99 (1.13–71.52)

0.04

Hypertension

0.40 (0.14–1.12)

0.08

    

Diabetes mellitus

0.42 (0.14–1.24)

0.12

    

Tubular atrophy (%)

0.91 (0.82–1.01)

0.08

    

Interstitial fibrosis (%)

0.96 (0.90–1.02)

0.15

    

Severity of AKI (KDIGO 2, 3 vs KDIGO 1)

2.65 (0.81–8.6)

0.11

    

Baseline eGFR (10 ml/min/1.73 m2)

1.12 (1.00–1.24)

0.04

  

1.05 (0.93–1.18)

0.41

Urinary protein-to-creatinine ratio (mg/mg)

0.75 (0.62–0.90)

0.002

  

0.88 (0.75–1.04)

0.14

Hemoglobin (g/dl)

1.33 (1.11–1.61)

0.003

1.26 (1.06–1.5)

0.008

1.28 (1.05–1.56)

0.01

Serum albumin (g/dl)

0.93 (0.58–1.51)

0.78

    

Concomitant use of ACEIs or ARBs

0.47 (0.13–1.66)

0.24

    

Concomitant use of immunosuppressants

0.64 (0.25–1.63)

0.35

    
  1. aIncludes complete recoveries and partial recoveries.
  2. bModel 3 included significant covariates in Model 1.
  3. ACEI, Angiotensin-converting enzyme inhibitor; AKI, acute kidney injury; ARB, angiotensin-II receptor blocker; eGFR, estimated glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; PRX3, peroxiredoxin 3.
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