Table 1 Association between genetic variants and serum urate/gout.

From: Effects of multiple genetic loci on the pathogenesis from serum urate to gout

SNP

Chr.

Position

Type

Gene

A1

A2

Serum Urate

Gout vs. HUA

Gout vs. Control

Β

P

PFDR

OR

P

PFDR

OR

P

PFDR

rs5438

1

9129620

5′ UTR

SLC2A5

T

C

−0.495

0.652

0.765

1.15

0.258

0.56

1.1

0.423

0.722

rs1061622

1

12252955

Coding

TNFRSF1B

G

T

−1.725

0.576

0.731

1.01

0.895

0.927

1.04

0.625

0.906

rs12129861

1

145725689

5upstream

PDZK1

A

G

−5.856

0.017

0.045

0.9

0.258

0.56

0.84

0.046

0.111

rs4971101

1

155157635

3downstream

TRIM46

G

A

7.667

1.49E-03

7.18E-03

1.2

0.024

0.139

1.37

3.36E-05

3.25E-04

rs2070803

1

155157715

3downstream

TRIM46

A

G

8.05

1.01E-03

5.86E-03

1.06

0.482

0.777

1.22

0.011

0.031

rs2027432

1

247578441

5upstream

NLRP3

A

G

−4.201

0.27

0.46

1.11

0.453

0.777

1.01

0.952

0.985

rs7512998

1

247583221

Intronic

NLRP3

C

T

−1.12

0.66

0.765

1.1

0.465

0.777

1.01

0.905

0.985

rs1260326

2

27730940

Coding

GCKR

T

C

8.304

1.34E-04

1.30E-03

1.08

0.288

0.56

1.27

3.44E-04

1.43E-03

rs780094

2

27741237

Intronic

GCKR

T

C

8.128

2.03E-04

1.48E-03

1.08

0.289

0.56

1.27

2.44E-04

1.18E-03

rs16890979

4

9922167

Coding

SLC2A9

T

C

−24.654

0.014

0.042

0.47

0.087

0.362

0.36

4.80E-03

0.015

rs1481012

4

89039082

Intronic

ABCG2

G

A

27.555

3.50E-31

1.02E-29

1.56

1.27E-10

3.68E-09

2.5

5.33E-45

1.55E-43

rs2231137

4

89061114

Coding

ABCG2

T

C

−16.945

2.33E-12

3.38E-11

0.91

0.254

0.56

0.67

8.23E-08

1.19E-06

rs231253

4

113362622

3′ UTR

ALPK1

C

G

0.121

0.971

0.971

1

1

1

0.99

0.914

0.985

rs742132

6

25607571

Intronic

LRRC16A

G

A

−3.605

0.099

0.192

1.1

0.236

0.56

1.02

0.824

0.985

rs9358890

6

25779392

Coding

SLC17A4

G

A

−4.741

0.052

0.108

1.27

9.02E-04

0.013

1.16

0.023

0.06

rs3799352

6

25822620

Intronic

SLC17A1

C

T

−7.456

5.35E-03

0.017

0.79

0.015

0.108

0.71

1.57E-04

1.08E-03

rs712221

6

152180241

Intronic

ESR1

A

T

−5.153

0.028

0.069

1.01

0.888

0.927

0.98

0.796

0.985

rs1178947

7

72850178

3′ UTR

FZD9

C

T

−1.042

0.934

0.971

1.04

0.736

0.897

1.02

0.837

0.985

rs1051921

7

73007943

3′ UTR

MLXIPL

A

G

−3.973

0.419

0.64

1.05

0.646

0.897

0.98

0.918

0.985

rs4994

8

37823798

Coding

ADRB3

G

A

0.728

0.944

0.971

0.82

0.042

0.203

0.84

0.051

0.114

rs2941484

8

76478768

3′ UTR

HNF4G

T

C

7.125

3.19E-03

0.012

1.09

0.233

0.56

1.28

1.87E-04

1.08E-03

rs10821905

10

52646093

5upstream

A1CF

A

G

11.401

0.038

0.085

1.47

8.85E-03

0.086

1.61

4.32E-04

1.57E-03

rs10749127

10

114849353

Intronic

TCF7L2

T

C

−7.631

1.79E-03

7.42E-03

1.14

0.11

0.4

0.96

0.593

0.905

rs505802

11

64357072

5upstream

SLC22A12

T

C

−1.899

0.482

0.665

0.96

0.681

0.897

0.91

0.233

0.451

rs11602903

11

64358241

5upstream

SLC22A12

T

A

−1.517

0.58

0.731

0.98

0.805

0.898

0.93

0.332

0.602

rs11231825

11

64360274

Coding

SLC22A12

C

T

−2.035

0.452

0.656

0.97

0.773

0.897

0.91

0.233

0.451

rs12273892

11

64480930

Coding

NRXN2

T

A

3.269

0.261

0.46

0.97

0.761

0.897

1.06

0.464

0.747

rs3184504

12

111884608

Coding

SH2B3

T

C

5.168

0.943

0.971

0.65

0.77

0.897

0.84

1

1

rs738409

22

44324727

Coding

PNPLA3

G

C

−1.595

0.302

0.487

1.03

0.663

0.897

0.98

0.842

0.985

  1. Chr., chromosome. HUA, hyperuricemia. A1, allele 1, effect allele. β values for SNP in serum urate were calculated by linear regression adjusted age and gender. P values for SNP in serum urate were calculated by deviance analysis for linear regression adjusted age and gender. P values for SNP in hyperuricemia and gout were calculated by Fisher’s exact test in addition model. PFDR value for SNP was multiple corrected by FDR method. SNPs were annotated by SNPnexus (http://www.snp-nexus.org/). Because of rs1137070 and rs5953210 in Chromosome X, they cannot be analyzed in this table. When PFDR < 0.05, it would be considered as significant and showed in bold.
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