Table 2 Association between genetic variants and serum urate/gout in gender subgroup.

From: Effects of multiple genetic loci on the pathogenesis from serum urate to gout

Gender

SNP

Gene

A1

A2

Serum Urate

Gout vs. HUA

Gout vs. Control

Gout vs. H + C

β

P

PFDR

OR

P

PFDR

OR

P

PFDR

OR

P

PFDR

Male

rs1051921

MLXIPL

A

G

−6.276

0.061

0.188

1.01

0.950

1.000

0.90

0.374

0.609

0.93

0.587

0.728

 

rs1061622

TNFRSF1B

G

T

−2.498

0.416

0.644

1.03

0.773

0.887

1.03

0.723

0.862

1.03

0.700

0.780

 

rs10749127

TCF7L2

T

C

−5.175

0.045

0.156

1.18

0.057

0.220

1.01

0.877

0.971

1.06

0.405

0.634

 

rs10821905

A1CF

A

G

10.908

0.071

0.200

1.61

3.41E-03

0.053

1.69

3.98E-04

2.06E-03

1.64

4.02E-04

3.12E-03

 

rs11231825

SLC22A12

C

T

−1.858

0.712

0.883

0.97

0.754

0.887

0.93

0.371

0.609

0.94

0.455

0.641

 

rs1137070

MAOA

C

T

−0.796

0.712

0.883

1.11

0.161

0.367

1.11

0.142

0.294

1.11

0.128

0.296

 

rs11602903

SLC22A12

T

A

−1.118

0.907

0.965

0.96

0.687

0.852

0.93

0.439

0.648

0.94

0.478

0.645

 

rs1178947

FZD9

C

T

−2.784

0.332

0.587

1.00

1.000

1.000

0.95

0.699

0.862

0.96

0.789

0.815

 

rs12129861

PDZK1

A

G

−3.914

0.140

0.333

0.90

0.294

0.536

0.83

0.044

0.124

0.85

0.075

0.194

 

rs12273892

NRXN2

T

A

2.500

0.567

0.798

1.00

1.000

1.000

1.09

0.376

0.609

1.05

0.523

0.676

 

rs1260326

GCKR

T

C

9.271

1.11E-04

8.59E-04

1.06

0.439

0.680

1.27

7.36E-04

3.26E-03

1.19

8.78E-03

0.034

 

rs1481012

ABCG2

G

A

25.859

1.57E-24

4.87E-23

1.69

4.99E-12

1.55E-10

2.70

9.66E-44

2.99E-42

2.27

1.07E-33

3.32E-32

 

rs16890979

SLC2A9

T

C

−14.915

0.084

0.216

0.44

0.042

0.220

0.40

0.020

0.068

0.41

0.018

0.055

 

rs2027432

NLRP3

A

G

−4.867

0.244

0.474

1.27

0.117

0.367

1.08

0.598

0.843

1.14

0.330

0.602

 

rs2070803

TRIM46

A

G

6.827

0.039

0.152

1.06

0.498

0.726

1.16

0.075

0.194

1.12

0.142

0.296

 

rs2231137

ABCG2

T

C

−17.783

1.45E-11

2.25E-10

0.87

0.139

0.367

0.63

6.18E-09

9.58E-08

0.69

4.26E-06

6.60E-05

 

rs231253

ALPK1

C

G

−1.484

0.353

0.587

1.08

0.389

0.634

1.01

0.938

1.000

1.03

0.704

0.780

 

rs2941484

HNF4G

T

C

9.156

3.07E-04

1.90E-03

1.10

0.253

0.491

1.35

3.26E-05

2.86E-04

1.27

1.06E-03

6.59E-03

 

rs3184504

SH2B3

T

C

10.386

0.794

0.890

0.52

0.515

0.726

0.74

1.000

1.000

0.65

0.758

0.810

 

rs3799352

SLC17A1

C

T

−8.894

3.09E-03

0.016

0.79

0.032

0.220

0.67

3.69E-05

2.86E-04

0.71

2.90E-04

2.99E-03

 

rs4971101

TRIM46

G

A

6.650

0.030

0.132

1.19

0.049

0.220

1.30

1.35E-03

5.23E-03

1.27

3.02E-03

0.016

 

rs4994

ADRB3

G

A

1.839

0.559

0.798

0.81

0.055

0.220

0.85

0.126

0.294

0.84

0.074

0.194

 

rs505802

SLC22A12

T

C

−1.471

0.804

0.890

0.96

0.655

0.846

0.93

0.393

0.609

0.93

0.455

0.641

 

rs5438

SLC2A5

T

C

−0.187

0.965

0.965

1.22

0.146

0.367

1.15

0.259

0.501

1.18

0.177

0.343

 

rs5953210

MAOA

A

G

−0.184

0.965

0.965

1.10

0.239

0.491

1.11

0.139

0.294

1.11

0.143

0.296

 

rs712221

ESR1

A

T

−3.570

0.185

0.410

1.00

1.000

1.000

1.00

0.972

1.000

1.00

0.973

0.973

 

rs738409

PNPLA3

G

C

−0.571

0.798

0.890

1.05

0.552

0.744

1.02

0.800

0.918

1.03

0.674

0.780

 

rs742132

LRRC16A

G

A

−2.715

0.209

0.432

1.14

0.166

0.367

1.03

0.686

0.862

1.06

0.409

0.634

 

rs7512998

NLRP3

C

T

−1.459

0.594

0.801

1.22

0.164

0.367

1.06

0.650

0.862

1.11

0.407

0.634

 

rs780094

GCKR

T

C

9.331

8.68E-05

8.59E-04

1.08

0.354

0.610

1.28

3.92E-04

2.06E-03

1.20

5.35E-03

0.024

 

rs9358890

SLC17A4

G

A

−2.525

0.360

0.587

1.23

6.77E-03

0.070

1.18

0.025

0.078

1.19

0.010

0.035

Female

rs1051921

MLXIPL

A

G

2.018

0.512

0.755

0.96

1.000

1.000

1.01

1.000

1.000

1.00

1.000

1.000

 

rs1061622

TNFRSF1B

G

T

1.012

0.938

0.949

1.08

0.858

1.000

1.18

0.593

0.973

1.14

0.721

1.000

 

rs10749127

TCF7L2

T

C

−13.689

8.02E-03

0.062

0.72

0.501

1.000

0.59

0.161

0.776

0.63

0.210

0.887

 

rs10821905

A1CF

A

G

9.054

0.234

0.604

1.09

0.754

1.000

1.33

0.499

0.973

1.25

0.733

1.000

 

rs11231825

SLC22A12

C

T

−4.161

0.427

0.661

0.71

0.489

1.000

0.63

0.254

0.876

0.65

0.257

0.887

 

rs1137070

MAOA

C

T

0.746

0.949

0.949

0.98

1.000

1.000

1.06

0.886

1.000

1.04

0.887

1.000

 

rs11602903

SLC22A12

T

A

−4.131

0.424

0.661

0.91

0.865

1.000

0.80

0.626

0.973

0.83

0.744

1.000

 

rs1178947

FZD9

C

T

3.361

0.409

0.661

0.96

1.000

1.000

1.00

1.000

1.000

0.99

1.000

1.000

 

rs12129861

PDZK1

A

G

−8.623

0.107

0.367

1.19

0.594

1.000

1.18

0.602

0.973

1.18

0.602

1.000

 

rs12273892

NRXN2

T

A

8.449

0.232

0.604

0.68

0.378

1.000

0.78

0.593

0.973

0.75

0.595

1.000

 

rs1260326

GCKR

T

C

5.820

0.280

0.661

1.04

1.000

1.000

1.15

0.673

0.994

1.12

0.779

1.000

 

rs1481012

ABCG2

G

A

30.660

2.41E-11

7.47E-10

1.32

0.386

1.000

2.22

6.57E-03

0.180

1.92

0.028

0.432

 

rs16890979

SLC2A9

T

C

−46.523

7.56E-03

0.062

0.63

1.000

1.000

0.13

1.000

1.000

0.16

1.000

1.000

 

rs2027432

NLRP3

A

G

5.824

0.943

0.949

0.23

0.167

1.000

0.24

0.175

0.776

0.24

0.178

0.887

 

rs2070803

TRIM46

A

G

10.988

0.021

0.110

1.45

0.239

1.000

1.92

0.047

0.487

1.75

0.079

0.809

 

rs2231137

ABCG2

T

C

−11.273

4.71E-03

0.062

0.91

0.868

1.000

0.74

0.434

0.973

0.78

0.529

1.000

 

rs231253

ALPK1

C

G

5.770

0.186

0.577

0.80

0.634

1.000

0.93

1.000

1.000

0.89

0.875

1.000

 

rs2941484

HNF4G

T

C

2.492

0.727

0.939

1.59

0.133

1.000

1.64

0.103

0.776

1.61

0.104

0.809

 

rs3184504

SH2B3

T

C

8.782

0.936

0.949

0.42

1.000

1.000

0.47

1.000

1.000

0.46

1.000

1.000

 

rs3799352

SLC17A1

C

T

−6.267

0.568

0.800

1.08

0.858

1.000

1.19

0.589

0.973

1.15

0.720

1.000

 

rs4971101

TRIM46

G

A

10.475

0.046

0.178

1.75

0.065

1.000

2.22

0.012

0.180

2.08

0.015

0.432

 

rs4994

ADRB3

G

A

−0.013

0.720

0.939

0.52

0.241

1.000

0.49

0.142

0.776

0.50

0.193

0.887

 

rs505802

SLC22A12

T

C

−4.249

0.384

0.661

0.70

0.394

1.000

0.62

0.254

0.876

0.64

0.257

0.887

 

rs5438

SLC2A5

T

C

−5.789

0.763

0.939

0.83

1.000

1.000

0.83

1.000

1.000

0.83

1.000

1.000

 

rs5953210

MAOA

A

G

1.592

0.937

0.949

0.74

0.377

1.000

0.79

0.472

0.973

0.78

0.472

1.000

 

rs712221

ESR1

A

T

−8.678

0.031

0.135

1.11

0.774

1.000

1.00

1.000

1.000

1.03

1.000

1.000

 

rs738409

PNPLA3

G

C

−3.785

0.390

0.661

1.35

0.300

1.000

1.25

0.471

0.973

1.28

0.390

1.000

 

rs742132

LRRC16A

G

A

−3.901

0.421

0.661

1.25

0.505

1.000

1.19

0.628

0.973

1.20

0.521

1.000

 

rs7512998

NLRP3

C

T

7.200

0.788

0.939

0.65

0.611

1.000

0.72

0.794

1.000

0.70

0.795

1.000

 

rs780094

GCKR

T

C

4.899

0.391

0.661

1.08

0.885

1.000

1.19

0.574

0.973

1.16

0.674

1.000

 

rs9358890

SLC17A4

G

A

−8.295

0.015

0.090

1.15

0.665

1.000

0.94

0.889

1.000

1.00

1.000

1.000

  1. A1, allele 1, effect allele. HUA, hyperuricemia. H + C, hyperuricemia plus control. β values for SNP in serum urate were calculated by linear regression adjusted age and gender. P values for SNP in serum urate were calculated by deviance analysis for linear regression adjusted age and gender. P values for SNP in hyperuricemia and gout were calculated by Fisher’s exact test in addition model. PFDR value for SNP was multiple corrected by FDR method. When PFDR < 0.05, it would be considered as significant and showed in bold.
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