Table 2 Univariate analysis of prognostic factors involved in survival.

From: PD-L1 predicts poor prognosis for nasopharyngeal carcinoma irrespective of PD-1 and EBV-DNA load

Ā 

Cases (nā€‰=ā€‰99)

PFS

OS

Variables

X 2

P value 1

X 2

P value 1

Gender

Male

68

0.725

0.394

0.344

0.558

Female

31

Ā Ā Ā Ā 

Age (years)

<50

60

2.327

0.127

5.551

0.018*

ā‰„50

39

Ā Ā Ā Ā 

Tumour size

rT1-3

71

5.030

0.025 *

6.959

0.008 **

rT4

28

Ā Ā Ā Ā 

Nodal status

N0-1

54

2.227

0.136

0.005

0.941

N2-3

45

Ā Ā Ā Ā 

Clinical stage3

I-III

65

2.306

0.129

4.372

0.037 *

IV

34

Ā Ā Ā Ā 

GTVnx (mm3)2

<29.6

45

5.049

0.025 *

8.090

0.004 **

ā‰„29.6

54

Ā Ā Ā Ā 

EBV-DNA load

undetectable

22

0.324

0.569

0.005

0.942

detectable

77

Ā Ā Ā Ā 

Treatment

IMRT

10

2.273

0.132

1.020

0.312

IMRT+CT

89

Ā Ā Ā Ā 

PD-1 positivity

negative

55

0.251

0.616

0.334

0.563

positive

44

Ā Ā Ā Ā 

PD-L1 H-score2

<155

38

2.327

0.127

5.870

0.015 *

ā‰„155

61

Ā Ā Ā Ā 
  1. 1Log-rank test.
  2. 2The optimal cut-off points for GTVnx and the PD-L1 H-score were determined by the receiver operating characteristic (ROC) curve for overall survival (OS).
  3. 3According to the 7th Edition of the AJCC/UICC Staging System for Nasopharyngeal Cancer. *Pā€‰<ā€‰0.05, **Pā€‰<ā€‰0.01, ***Pā€‰<ā€‰0.001.
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