Table 1 CVD disease genes targeted by SBP’s plasma absorbed compounds (SBPpc).

From: A network-based method for mechanistic investigation of Shexiang Baoxin Pill’s treatment of cardiovascular diseases

No

Gene Symbol

Gene function

1

COL1A1

Platelet-derived growth factor binding protein44

2

CYP2C9

Heme binding protein45

3

ESR2

A group of heme-thiolate monooxygenases46

4

ICAM1

Ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)47

5

LDLR

Receptor of low-density lipoprotein (plasma cholesterol apolipoprotein)48

6

MMP9

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration49.

7

NOS3

Modulate angiogenesis, blood pressure, and calcium channel50

8

COX-2

Regulate vasoconstriction and blood pressure51

9

TGFB1

Regulation of vascular endothelial cell migration52

10

TLR4

Immune response and inflammatory process regulation53

11

VCAM1

Involved in calcium-mediated signaling pathways of intracellular calcium source54