Table 1 CVD disease genes targeted by SBP’s plasma absorbed compounds (SBPpc).
No | Gene Symbol | Gene function |
---|---|---|
1 | COL1A1 | Platelet-derived growth factor binding protein44 |
2 | CYP2C9 | Heme binding protein45 |
3 | ESR2 | A group of heme-thiolate monooxygenases46 |
4 | ICAM1 | Ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)47 |
5 | LDLR | Receptor of low-density lipoprotein (plasma cholesterol apolipoprotein)48 |
6 | MMP9 | May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration49. |
7 | NOS3 | Modulate angiogenesis, blood pressure, and calcium channel50 |
8 | COX-2 | Regulate vasoconstriction and blood pressure51 |
9 | TGFB1 | Regulation of vascular endothelial cell migration52 |
10 | TLR4 | Immune response and inflammatory process regulation53 |
11 | VCAM1 | Involved in calcium-mediated signaling pathways of intracellular calcium source54 |