Figure 5: Epigenetic profiling of aorta macrophages from CIH-exposed mice. | Scientific Reports

Figure 5: Epigenetic profiling of aorta macrophages from CIH-exposed mice.

From: Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36

Figure 5

(A) Top ten over-represented canonical pathways among H3K9ac enriched regions. The length of the bar represents the statistical significance from the hypergeometric test expressed as −log(p-value). Vertical dashed blue line represent the significance cutoff (−log(p-value = 0.05) = 1.3). (B) Top ten over-represented canonical pathways among H3K27me3 enriched regions. Significance values are expressed as in panel A. (C) Example of non-directional gene network of genes bearing H3K9ac marks. Genes bearing the mark are colored green. Molecules related to immune response are highlighted in purple. (D) Example of non-directional gene network of genes bearing H3K27me3 marks. Genes bearing the mark are colored red. Molecules related to immune response are highlighted in purple. (E) Analysis of candidate genes by single-locus qPCR analysis. Green and red bars represent the CIH/RA fold change enrichment for the H3K9ac and H3K27me3 marks, respectively. Dashed horizontal blue line represents the cutoff value for fold change enrichment (CIH/RA FCE = 1). All data reflect n = 8/experimental condition.

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