Figure 2: Validation of candidate protein biomarkers by microarray ELISAs. | Scientific Reports

Figure 2: Validation of candidate protein biomarkers by microarray ELISAs.

From: Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis

Figure 2

Panel A shows that expression levels of the four candidate biomarkers were significantly different in the acute phase of KD compared to the recovery phase of KD patients or healthy subjects. Panel B shows that the expression levels were significantly different in patients during the acute phase of KD compared to patients with other illnesses (G1: viral infections, G2: bacterial infections, and G3: autoimmune disease in childhood), except for LBP and AGT in G2. Microarray ELISAs were performed for LBP, LRG1, AGT, and RBP4, as described in the Materials and Methods section. The sera used in this experiment are described in Tables S1 and S3. The horizontal lines and I bars indicate means and the SEMs, respectively. P values are used for the comparison of the expression level among the acute and recovery phases of KD and other illnesses; ***p < 0.001, **p < 0.01, *p < 0.1, NS: non-significant. Each mean ± SD is described in Table 2.

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