Table 1 Upregulated and downregulated proteins in the acute phase of KD identified by label-free relative quantitation analysis with shotgun LC-MS/MS analysis.

From: Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis

Acc No. *

Gene name

Description

Peptides **

Up-regulated

 P00450

CP

Ceruloplasmin

38

 P00736

C1R

Complement C1r subcomponent

5

 P00747

PLG

Plasminogen

9

 P00751

CFB

Complement factor B

37

 P01011

SERPINA3

Alpha-1-antichymotrypsin

86

 P01019

AGT

Angiotensinogen

6

 P02748

C9

Complement component C9

8

 P02750

LRG1

Leucine-rich alpha-2-glycoprotein

19

 P04114

APOB

Apolipoprotein B-100

9

 P05155

SERPING1

Plasma protease C1 inhibitor

8

 P09871

C1S

Complement C1s subcomponent

12

 P0C0L4

C4A

Complement C4-A

16

 P0C0L5

C4B

Complement C4-B

12

 P0DJI8

SAA1

Serum amyloid A-1 protein

6

 P10643

C7

Complement component C7

6

 P18428

LBP

Lipopolysaccharide-binding protein

26

 P19320

VCAM1

Vascular cell adhesion protein 1

5

 P25311

AZGP1

Zinc-alpha-2-glycoprotein

7

 Q06033

ITIH3

Inter-alpha-trypsin inhibitor heavy chain H3

7

 Q14624

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4

17

Down-regulated

 P02753

RBP4

Retinol-binding protein 4

6

 P02765

AHSG

Alpha-2-HS-glycoprotein

13

 P06396

GSN

Gelsolin

9

 P06727

APOA4

Apolipoprotein A-IV

7

 P19823

ITIH2

Inter-alpha-trypsin inhibitor heavy chain H2

8

 P19827

ITIH1

Inter-alpha-trypsin inhibitor heavy chain H1

12

  1. *Acc No.; Accession numbers of UniProtKB/Swiss-Prot database.
  2. **The number of peptides that were extracted using the following parameters in Progenesis LC-MS: max fold change ≥2, ANOVA p < 0.001, and the average of normalized abundance (higher condition in Progenesis LC-MS) ≥500.
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