Figure 5: DR reversed the changed gene expression induced by DEN. | Scientific Reports

Figure 5: DR reversed the changed gene expression induced by DEN.

From: Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile

Figure 5

(a) Volcano plot illustrated the fold change and statistical significance of genes in DEN+DR group compared with the DEN group. (b) Venn diagram showing the overlap of genes regulated by DEN and DEN+DR to opposite direction. The pink rounds represented the up-regulated genes and blue rounds represented down-regulated genes. (c) Heatmap showed the expression of overlapping genes between DEN and DEN+DR group. (d) KEGG enrichment of genes regulated by DEN and DEN+DR in opposite direction. Black bars represented the genes up-regulated in DEN and down-regulated in DEN+DR, grey bars represented the genes down-regulated in DEN and up-regulated in DEN+DR. (e) Comparison of gene expression in MAPK pathway between DEN and DEN+DR: most of the genes were up-regulated by DEN and reversed by DR, and a few genes were regulated in the contrary way.

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