Figure 3: Opposing regulation of nerve growth factor and Rac signalling in DRG neurons.
From: Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons
Pathway analysis of enriched canonical pathways identifies opposing regulation of Rac signalling by 18/1 and 90/5 patterns of stimulation. Rac signalling pathways were oriented to depict extracellular, cytoplasmic, and nuclear sites of action. Nodes in the pathway are up- (25, red) or down-regulated (11, green) depending on the regulation of target pathway genes. Shaded targets reflect multiple regulated components (e.g. MAPK pathway in 18/1 stimulation pattern). Multiple downstream pathways interacting through Rac, e.g., actin polymerization, translation and membrane ruffling, affect neurite outgrowth and dynamics.
