Figure 4: Enrichment of activity-regulated transcription factor binding sites.
From: Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons
Hierarchical clustering of 311 TFBS by site and condition. Cis-regulatory elements identified through evolutionary conserved regions (ECRs), promoters, and 5′-UTRs are clustered by % occurrence within a gene set and by importance factor (TF abundance X TF weighting) for 18/1 and 90/5 stimulation patterns at 2 hr and 5 hr. Background gene sets (305 genes) were determined by filtering microarray data to identify genes not regulated by either pattern at 2 hr and 5 hr (fold-change < |1.4|), and used to calculate weighting for TF analysis. Enriched TFBS are annotated for both % abundance and importance.
