Figure 5: Top 10 candidate transcription factor binding sites enriched by stimulus pattern and duration.
From: Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons
Top 10 candidate cis-regulatory elements are shown for genes activated by the 18/1 (A) and 90/5 (B) stimulation patterns after 2 hr and 5 hr. Importance factor scores >0.2 may be functionally significant as measured by enriched datasets for NF-κB and CREB binding site and downstream regulators of MAPK signalling in DRG neurons (Figure S2). Several candidate sites have high importance factor scores for multiple conditions, e.g. Tef. The TFBS used for this analysis are not differentiated by enhancer, repressor, or activation.
