Figure 6: Raffinose increases expression of genes involved in keratinocyte differentiation in the skin of hairless mice. | Scientific Reports

Figure 6: Raffinose increases expression of genes involved in keratinocyte differentiation in the skin of hairless mice.

From: The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor

Figure 6

Hairless mice were treated topically twice a day for 4 days with 1 and 5% raffinose in ointment formulation. Control mice were treated with the base without raffinose. (a) Histological appearance of mouse skin was shown with H & E staining. 100 x magnification (left). Epidermal thickness of dorsal skin was measured at twelve sites in histological sections of three mice in each experimental group (right). Values are mean ± SEM (n = 3). *P < 0.05 compared with control. (b) Immunohistochemical staining for involucrin, filaggrin, SCD1, ChREBP, AQP3, and LXR in control and 5% raffinose-treated mouse skin. 100x magnification.

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