Figure 2: Topological Data Analysis of the INO80 deletion network.
From: Identification of Topological Network Modules in Perturbed Protein Interaction Networks
(A) TDA was used to analyze the fold-change ratios of 149 proteins detected from the AP-MS analysis of the INO80 deletion strains. Panel (A) represents a complete view of the network, while on the right side (B) the network is separated into eight modules. Filters with correlation metric were used such as resolution and gain were set at 30 and 3.0x eq. in (A), and 45 and 3.0x eq. in (B). (C,H) Individual TNMs, highlighted in white in the corresponding right panel, are mapped onto the main network, highlighted in red in the corresponding left panel. TNMs were numbered in order to emphasize their locations within the topological network structure. In (A–H), protein nodes are colored based on the metric PCA2. Color bar: red: high values, blue: low values. Node size is proportional to the number of proteins in the node.
