Figure 3: Overall model of the INO80 deletion network.
From: Identification of Topological Network Modules in Perturbed Protein Interaction Networks
Enrichment Analysis (A) and (B) Altered protein interactions in TNMs 1 and 2 were searched for biological pathways and molecular functions enrichment using WebGestalt36 and DAVID37 annotation tools. The top 4 enriched terms in biological pathways and MF as indicated by their significant p-values are illustrated in (A) and (B). (C) and (D) Network visualization of the overlap interactions within TMNs 1 (C) and 2 (D) and Biogrid database38. The protein networks were built using Cytoscape51. Changes in abundance of proteins within TNMs 1 and 2. (E) Proteins in TNM1 were plotted using their corresponding fold-ratios in the four mutants of the NHP10 and ARP8 modules. (F) Proteins in TNM2 were plotted using their corresponding fold-ratios in the two mutants of the NHP10 module.
