Figure 4: Construction of a low-dimensional structure of the INO80 complex.
From: Identification of Topological Network Modules in Perturbed Protein Interaction Networks
(A) Proteins were assembled based on the clustering results. Here we illustrated the relationship between proteins in the ARP5 and ARP8 modules and the display the final assembled complex. Red corresponds to the proteins in the NHP10 submodule, blue corresponds to the proteins in the ARP8 module and the ARP5 module was colored in green. Proteins that were not significantly altered by the mutants are colored in grey. The size of the inset circles corresponds to the molecular weights of the proteins illustrated. (B) Ino80 structural modules were mapped onto the overall network module generated by TDA. In addition, the localization of biological functions provided by GeneMANIA40 was mapped onto their general location of the TDA network.
