Figure 8: Cancer stem cells gene expression pattern and correlation with cell mechanics.

(a) PC-corr gene network constructed using cut-off 0.65. The three looped-dashed lines indicate three significant pathways, while yellow different symbols highlight the enriched genes classified as GO terms. (b) Linear regression plot of z-score of PC1 and z-score of elastic modulus for each cell culture condition. Each point represent the PC1-score-average vs the elastic-modulus-average of all the samples in the given cell culture condition. The standard error for each computed average is reported as an error bar. (c) For cut-off = 0.65, the gene difference between the PC-corr and P-value networks in the nodes and edges are illustrated in the proportional Venn diagrams. Some genes are only present in the PC-corr network, like the genes reported in the box on the left. Only 10 gene interactions present in the PC-corr are present in the P-value network too.