Figure 4: Histology of mouse hearts. | Scientific Reports

Figure 4: Histology of mouse hearts.

From: MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression

Figure 4

(A) Left panel: representative cross-sections of hearts from control and β1-immunized (AdrB1+) mice stained with isolectin B4 (green) and wheat germ agglutinin (red). Scale bar, 50 μm. Right panel: columns indicate the respective myocyte area and capillary density from same sections in each group, showing cardiomyocyte hypertrophy compensated by higher capillary density in hearts from immunized mice. (B) Quantification of collagen infiltration with sirius red staining. (C,D) Quantification of inflammatory infiltration with CD11b and CD45 stainings. *P ≤ 0.0.05; **P ≤ 0.0.01 vs control. n = 7–10 mice per group.

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