Table 1 Suggestive shared signals (P < 1E-04) between giant cell arteritis and Takayasu’s arteritis outside the HLA region.

From: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy

Chr

SNP

BP (GRCh37)

Locus

Change

META LVV

META GCA

META TAK

P

Q

OR [95% CI]

P

Q

OR [95% CI]

P

Q

5

rs755374

158,829,294

IL12B

T < C

7.54E-07

0.14

1.19 [1.06–1.33]

3.92E-03

0.69

1.50 [1.26–1.78]

4.71E-06

0.47

16

rs1448258

10,151,357

GRIN2A

T < C

2.69E-06

0.54

1.23 [1.10–1.37]

1.70E-04

0.37

1.29 [1.08–1.53]

4.48E-03

0.28

9

rs28489139

139,232,033

GPSM1

G < A

1.38E-05

0.10

1.27 [1.04–1.55]

1.71E-02

0.40

1.98 [1.45–2.69]

1.52E-05

0.80

17

rs7406657

26,083,690

NOS2

C < G

2.65E-05

0.62

0.76 [0.66–0.86]

2.80E-05

0.79

0.88 [0.73–1.06]

1.87E-01

0.80

17

rs4796017

26,074,991

NOS2

G < A

3.58E-05

0.26

0.79 [0.71–0.88]

2.73E-05

0.17

0.91 [0.77–1.07]

2.48E-01

0.61

17

rs7207044

26,075,524

NOS2

A < G

3.81E-05

0.21

0.79 [0.70–0.88]

2.56E-05

0.14

0.91 [0.77–1.08]

2.67E-01

0.56

2

rs17438590

185,948,301

LOC105373782

A < T

4.86E-05

0.74

0.73 [0.60–0.89]

1.38E-03

0.79

0.68 [0.51–0.92]

1.14E-02

0.31

1

rs7340058

155,334,933

ASH1L

A < G

6.26E-05

0.62

0.61 [0.45–0.83]

1.70E-03

0.74

0.58 [0.38–0.89]

1.28E-02

0.20

2

rs58794562

185,949,321

LOC105373782

T < A

6.36E-05

0.71

0.74 [0.61–0.89]

1.83E-03

0.74

0.68 [0.51–0.92]

1.10E-02

0.30

17

rs9898308

26,059,738

NOS2

G < T

6.50E-05

0.29

0.79 [0.71–0.89]

4.50E-05

0.21

0.91 [0.77–1.08]

2.80E-01

0.57

17

rs4796023

26,078,694

NOS2

C < T

6.59E-05

0.07

0.78 [0.70–0.87]

1.50E-05

0.06

0.94 [0.80–1.11]

4.79E-01

0.58

2

rs79657074

61,116,590

REL

T < A

6.73E-05

0.28

1.32 [1.01–1.72]

4.42E-02

0.29

1.82 [1.33–2.48]

1.62E-04

0.55

17

rs10852932

2,143,460

SMG6

T < G

6.88E-05

0.24

0.83 [0.74–0.93]

1.53E-03

0.64

0.80 [0.66–0.96]

1.45E-02

0.05

4

rs4032303

67,463,707

Intergenic

T < C

7.01E-05

0.20

1.32 [1.16–1.50]

2.54E-05

0.51

1.09 [0.89–1.32]

4.09E-01

0.21

7

rs2690884

31,307,585

Intergenic

G < A

7.72E-05

0.51

0.81 [0.72–0.91]

2.88E-04

0.52

0.86 [0.71–1.03]

9.68E-02

0.20

2

rs78848661

185,999,116

LOC105373782

T < C

7.79E-05

0.66

0.75 [0.62–0.90]

2.71E-03

0.74

0.67 [0.50–0.90]

8.27E-03

0.29

10

rs587198

6,531,149

PRKCQ

C < T

7.87E-05

0.93

1.20 [1.08–1.34]

1.16E-03

0.67

1.22 [1.03–1.44]

2.47E-02

0.60

17

rs4471732

26,061,232

NOS2

G < A

8.38E-05

0.29

0.80 [0.71–0.89]

6.95E-05

0.19

0.91 [0.77–1.07]

2.62E-01

0.55

5

rs2255637

96,249,378

ERAP1

A < C

8.77E-05

0.48

1.18 [1.06–1.31]

3.13E-03

0.84

1.27 [1.06–1.51]

7.57E-03

0.16

17

rs12450521

26,083,392

NOS2

A < C

8.85E-05

0.72

0.77 [0.67–0.88]

1.51E-04

0.59

0.87 [0.72–1.05]

1.55E-01

0.84

15

rs4533267

100,786,271

ADAMTS17

A < G

9.63E-05

0.50

0.78 [0.69–0.88]

7.17E-05

0.85

0.91 [0.75–1.09]

3.00E-01

0.40

2

rs7349232

181,953,354

UBE2E3

T < C

9.84E-05

0.93

1.24 [1.09–1.41]

1.09E-03

0.50

1.25 [1.02–1.53]

3.39E-02

0.90

14

rs61981699

81,064,877

CEP128

T < C

9.88E-05

0.35

1.31 [1.13–1.52]

3.91E-04

0.15

1.23 [0.96–1.57]

9.68E-02

0.32

5

rs6874656

96,234,375

ERAP1

C < T

9.95E-05

0.46

1.18 [1.06–1.31]

3.20E-03

0.75

1.26 [1.06–1.50]

8.69E-03

0.15

5

rs251339

96,235,038

ERAP1

T < C

9.96E-05

0.72

1.19 [1.07–1.33]

1.64E-03

0.80

1.23 [1.03–1.46]

2.13E-02

0.27

  1. BP, base-pair; CI, confidence interval; Chr, chromosome; GCA, giant cell arteritis; GRCh37, Genome Reference Consortium Human genome build 37; LVV, large vessel vasculitis; OR, odds ratio for the minor allele; Q, Cochran’s Q test P-value; SNP, single-nucleotide polymorphism; TAK, Takayasu’s arteritis.
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