Figure 7: Cell type-specific and constitutive transcription profiles of xenobiotic-metabolizing enzymes in human immune cell subtypes.
From: Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop
Human immune cells were isolated from at least seven different donors for each cell type and analyzed without incubation. HepG2 cell line was used as control. Heatmaps show log2-transformed relative transcription levels of (a) control genes (CMA1 and KIT) or of (b) left, CYP1 enzymes (phase I), (b) middle, other detoxifying enzymes (phase I and II) and (b) right, transporter proteins (phase III). Each row represents one subject; each column represents one gene. Black squares represent not-detected transcripts.
