Figure 2: Histamine deficiency aggravated cardiac remodeling and dysfunction post-MI.

(a) The cumulative survival rate of HDC−/− and WT mice post-MI. (b) H&E staining showed that histamine deficiency caused larger infarct size in HDC−/− mice than WT mice at 4 weeks post-MI (scale bar = 500 μm; n = 8–10). (c) Representative echocardiographic images. (d–f) More serious dilative cardiac remodeling and worse cardiac function in HDC−/− mice than WT mice post-MI (n = 8–10). NS, not statistically significant, *p < 0.05, **p < 0.01, ***p < 0.001.