Figure 4: Histamine deficiency increased proinflammatory and profibrotic cytokines levels post-MI. | Scientific Reports

Figure 4: Histamine deficiency increased proinflammatory and profibrotic cytokines levels post-MI.

From: Aggravated myocardial infarction-induced cardiac remodeling and heart failure in histamine-deficient mice

Figure 4

(a,b) IL-6 (a) and TGF-β1 (b) levels in the serum of HDC−/− mice and WT mice at 4 weeks post-MI were measured by ELISA (n = 6). (c) FACS data showed the percentage of CD11b+ myeloid cell numbers in the blood of HDC−/− mice and WT mice at 4 weeks post-MI (n = 8). (d) The neonatal heart fibroblast proliferation rates were measured by the CCK-8 assay (n = 6). (e) TGF-β1 levels were measured by ELISA in the supernatant of CD11b+ myeloid cells (n = 6). NS, not statistically significant, *p < 0.05, **p < 0.01, ***p < 0.001.

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