Figure 7: Effects of M2 depletion on the MCP-1/sSiglec-9-mediated recovery from ALF in rats. | Scientific Reports

Figure 7: Effects of M2 depletion on the MCP-1/sSiglec-9-mediated recovery from ALF in rats.

From: Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity

Figure 7

(a) Gene expressions in ALF livers treated with MCP-1/sSiglec-9 together with m-Clodrosome or m-Encapsome 36 h after D-Gal injection (n ≥ 4 animals per group). The results are expressed relative to the mRNA expression level in the sham-operated model. Data represent the mean ± SEM; ∗P < 0.05, ∗∗P < 0.01. m-Clodrosome, Mannosylated Clodronate liposomes; m-Encapsome, Mannosylated control liposomes. (b) Representative images of HE-stained livers. Treatment with m-Clodrosome abolished the MCP-1/sSiglec-9-mediated recovery from ALF. Scale bar: 100 μm. (c) Quantification of serum liver enzymes at 36 h after D-Gal injection. Data represent the mean ± SEM; ∗P < 0.05.

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