Figure 1: The quinoline core structure and examples of R4 substituents that differently influenced insulin secretion in RIN-5AH beta cells. | Scientific Reports

Figure 1: The quinoline core structure and examples of R4 substituents that differently influenced insulin secretion in RIN-5AH beta cells.

From: Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue

Figure 1

Quinoline core structure is displayed at top. The three groups of R4 substituents are displayed below. “Preferable” represent a group of molecules where at least 4 derivatives with the same R4 substituent increased insulin secretion by at least 40% (first row) or if exclusive replacement of R4 group didn’t decrease insulin secretion of an efficient derivative (second row). “Tolerable” R4 groups don’t necessarily spoil the effect, depending on the R6,7,8 substituents. Third group represents derivatives with undesirable changes where if replacements carried out solely with any of the indicated R4 substituents spoiled the effect of its efficient derivative. Q denotes connection to quinoline ring through R4 position. For more details please see Supplementary Table 1.

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