Table 2 Association analysis for 39 SNPs covering the region of the EFNB3 gene with an additional 10 kb 5′ and 3′ of the gene for the combined male and female sample, the male-only sample and the female-only sample.

From: Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene

SNP ID

Position Chromosome 17 (Build 37/hg19)

Coding Allele

Alternate Allele

Minor Allele

aMAF

All

Males

Females

bp-value Association

β coefficient logistic Regresssion

Odds Ratio for Coding Allele

bp-value Association

β coefficient logistic Regresssion

Odds Ratio for Coding Allele

bp-value Association

β coefficient logistic Regresssion

Odds Ratio for Coding Allele

rs12939910

7599260

G

C

G

0.083

0.12477

−0.187

0.812

0.02836

−0.328785

0.734155

0.87478

0.033

1.001

rs12938947

7599665

A

G

A

0.082

0.10526

−0.199

0.805

0.02693

−0.334713

0.729201

0.96505

0.009

0.989

rs12950295

7599851

C

T

C

0.175

0.07954

−0.166

0.854

0.16536

−0.160257

0.854119

0.20450

−0.209

0.840

rs12939581

7599859

A

G

A

0.083

0.04861

−0.241

0.778

0.03350

−0.316053

0.726025

0.48343

−0.152

0.900

rs11659090

7600926

G

A

G

0.175

0.21216

−0.117

0.877

0.25533

−0.130554

0.867979

0.47988

−0.114

0.878

rs12941981

7608462

A

C

A

0.092

0.13720

−0.180

0.831

0.04492

−0.296001

0.764927

0.95660

0.011

0.988

c rs3744263

7613708

C

T

T

0.320

0.00034

0.253

1.317

0.00195

0.267526

1.36367

0.04734

0.242

1.242

rs3744262

7613765

A

G

G

0.365

0.00572

0.194

1.243

0.01931

0.201133

1.2752

0.10881

0.194

1.191

c rs7141

7614601

A

G

G

0.304

0.00026

0.268

1.319

0.00148

0.28582

1.36416

0.03779

0.261

1.249

rs56371490

7615143

T

C

C

0.362

0.01127

0.179

1.222

0.03116

0.187369

1.2527

0.13850

0.180

1.172

rs9907011

7615286

T

C

T

0.158

0.01191

−0.234

0.792

0.02361

−0.261224

0.771113

0.20641

−0.198

0.817

rs3948593

7615364

C

T

T

0.146

0.03067

0.208

1.238

0.07727

0.205784

1.2701

0.14138

0.250

1.169

rs62062589

7615476

C

G

G

0.352

0.01011

0.182

1.231

0.03060

0.187404

1.26038

0.11540

0.192

1.185

rs9906502

7615745

A

G

A

0.167

0.00860

−0.241

0.789

0.01752

−0.269905

0.766975

0.18733

−0.204

0.816

rs67022015

7617165

C

T

C

0.098

0.11132

−0.181

0.820

0.06851

−0.254179

0.769694

0.70236

−0.075

0.922

rs12943024

7617209

T

C

T

0.096

0.08925

−0.195

0.812

0.05425

−0.270334

0.760844

0.67087

−0.084

0.918

rs62062590

7617378

A

G

A

0.317

0.01447

0.177

1.271

0.00985

0.222777

1.34282

0.40259

0.109

1.154

rs35547626

7617558

C

T

C

0.320

0.03598

0.153

1.242

0.03252

0.186881

1.29198

0.43058

0.103

1.160

rs62062591

7617572

A

C

A

0,317

0.02770

0.160

1.249

0.02400

0.196057

1.30176

0.41011

0.108

1.161

rs11867748

7617662

A

C

A

0.098

0.10942

−0.182

0.819

0.06586

−0.257191

0.766705

0.70787

−0.073

0.924

rs11870307

7617787

G

A

A

0.202

0.00298

0.257

1.269

0.01832

0.24949

1.29048

0.05062

0.290

1.241

rs60370790

7617955

A

G

A

0.361

0.26425

0.079

1.038

0.57855

0.0481182

1.027

0.27390

0.135

1.058

rs62062593

7618026

C

T

C

0.309

0.02570

0.162

1.257

0.01802

0.204916

1.32361

0.46836

0.095

1.147

rs11651917

7618604

A

G

A

0.301

0.03249

0.156

1.253

0.01914

0.203731

1.32687

0.55684

0.077

1.131

rs34873228

7618737

T

C

T

0.098

0.09977

−0.188

0.818

0.06709

−0.256201

0.767848

0.65493

−0.088

0.921

rs1123547

7619861

C

T

C

0.363

0.25014

0.081

1.041

0.56717

0.0492604

1.02779

0.25625

0.138

1.067

rs7208469

7619871

A

G

A

0.303

0.02661

0.161

1.259

0.01474

0.211384

1.3393

0.56536

0.075

1.127

rs4246412

7620595

T

G

T

0.363

0.24388

0.082

1.043

0.58159

0.0472188

1.02484

0.22775

0.146

1.078

rs4968206

7620702

G

T

G

0.477

0.85398

0.012

0.963

0.72738

−0.0287709

0.936648

0.44371

0.090

1.013

rs4968207

7620907

G

C

G

0.355

0.36763

0.064

1.025

0.70825

0.0324189

1.01287

0.31750

0.122

1.049

rs3803802

7621464

A

C

A

0.465

0.76738

0.020

0.971

0.73459

−0.027465

0.936317

0.37628

0.101

1.038

rs7359524

7621528

A

G

A

0.294

0.02767

0.162

1.257

0.01413

0.215663

1.34071

0.60819

0.068

1.121

rs58049067

7621561

C

T

C

0.097

0.13675

−0.172

0.830

0.07388

−0.254645

0.771343

0.81378

−0.047

0.950

rs1544724

7621777

G

T

G

0.464

0.78804

0.018

0.970

0.73992

−0.0269205

0.937495

0.40859

0.095

1.033

rs1544725

7621877

A

C

A

0.087

0.10294

−0.197

0.800

0.07950

−0.260991

0.756051

0.56762

−0.119

0.896

rs3744260

7621943

A

G

A

0.366

0.22459

0.085

1.043

0.45851

0.06344

1.03401

0.30109

0.125

1.061

rs3744259

7622209

A

G

A

0.363

0.25200

0.081

1.041

0.58521

0.046926

1.02387

0.23738

0.144

1.075

rs3744258

7623394

G

A

G

0.368

0.26200

0.080

1.035

0.50276

0.0585537

1.02531

0.33854

0.118

1.052

rs307629

7624326

C

T

C

0.100

0.56032

−0.071

0.908

0.26781

−0.165516

0.846448

0.72667

0.072

1.036

  1. aMAF = minor allele frequency.
  2. bBonferroni corrected p-value for 3 categories (all, male, female) X 8 tag SNPs = 8 LD blocks = 24 independent tests = 0.05/21 = 0.002381; Bonferroni significant p-values are in bold.
  3. crs: reference SNP cluster ID. rs7141 and rs3744263: the two Bonferroni significant SNPs, are in LD at r2 = 0.896 in Utah CEU population (SNAP version 2.2 Broad Institute, 1000 genomes data).
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