Figure 1: Glutamate was increased in the plasma of diabetics in vivo and in the supernatant of RINm5f cells exposed to high glucose in vitro. | Scientific Reports

Figure 1: Glutamate was increased in the plasma of diabetics in vivo and in the supernatant of RINm5f cells exposed to high glucose in vitro.

From: An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes

Figure 1

(a) The concentration of glutamate in the plasma of normal or diabetic patients (*p < 0.05 vs Normal). (b) The concentration of glutamate in the plasma of control or diabetic mice (n = 14, *p < 0.05 vs Control). (c) The concentration of glutamate in the supernatant of cultured RINm5f β-cells treated with 33.3 mM glucose for 72 h and/or GDH (20 unit/mL) (n = 5, *p < 0.05 vs control, #p < 0.05 vs HG). (d) Effect of GDH (20 unit/mL) treatment for 72 h on the cell viability of RINm5f β-cells (n = 9). (e) Effect of GDH treatment on insulin secretion from RINm5f β-cells incubated with 33.3 mM glucose for 72 h (n = 5, *p < 0.05 vs control, #p < 0.05 vs HG).

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