Figure 7: Memantine treatment inhibited the cleaved caspase-3 expression in rat islets. | Scientific Reports

Figure 7: Memantine treatment inhibited the cleaved caspase-3 expression in rat islets.

From: An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes

Figure 7

Immunofluorescence staining of pancreatic sections from control and diabetic mice treated with or without Memantine. Pancreatic sections were costained with anti-insulin (β cell; green) and anti- cleaved caspase-3 (red) antibodies (a), and the intensity of cleaved caspase-3-positive signals in the insulin-positive area was measured (b). (n = 5, *p < 0.05 vs control, #p < 0.05 vs diabetes).

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