Figure 1 | Scientific Reports

Figure 1

From: Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction

Figure 1

Principal component plot comprising all expressed RNA transcripts (a), differentially expressed RNA transcripts in all 3 tissue types (b) and heatmap of top 50 RNA transcripts affected by Ang II in vivo (c). (a) Top 3 principal components were calculated using expression intensities, normalized using robust spline normalization method, of approximately 16 000 RNA transcripts detected (detection p-value < 0.01) in all samples; (b) Three genes that expression is significantly changed in all 3 tissue types by Ang II infusion are depicted on Venn diagram, showing number of genes significantly affected by Ang II infusion in vivo in all 3 tissue types studied; (c) Heatmap depicts RNA transcripts most significantly affected by Ang II in vivo irrespectively of tissue type. Srpx = sushi-repeat containing protein, X-linked; Sphk1/2 = Sphingosine kinase 1/2; Mfap4 = microfibrillar-associated protein 4; PC = principal component.

Back to article page