Table 1 Ten genes present in the highest number of gene sets most significantly enriched in hypertension in thoracic aorta and mesenteric arteries and their expression fold change in hypertensive mice as compared to normotensive mice.

Thoracic aorta				Mesenteric arteries
Gene	Number of gene sets (out of 68)	log₂FC	Expression change–FDR adj. p value	Gene	Number of gene sets (out of 36)	log₂FC	Expression change–FDR adj. p value
Cdh13	30	0.595	0.0005	Igfbp3	9	0.17	0.11
Sphk1	29	1.221	0.0003	Eif5a	9	0.15	0.24
Sod1	29	0.191	0.0391	Inhba	8	0.19	0.39
Thy1	28	0.794	0.0013	Mast2	8	0.17	0.07
Tgfb1	22	0.284	0.0248	Cdc23	7	0.06	0.49
Nme2	21	0.283	0.0092	Ccdc88a	7	0.10	0.28
Col4a3	21	0.245	0.0278	Sphk1	7	0.40	0.04
Vegfa	20	0.330	0.0594	Apbb1	7	0.17	0.23
Angptl4	19	0.402	0.0426	Anapc5	7	0.18	0.17
Htatip2	18	0.835	0.0002	Ppp5c	6	0.09	0.41

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