Figure 7: Effect of ibuprofen on human fetal testis PGD2 and PGE2 production.
From: Ibuprofen results in alterations of human fetal testis development
(A–C) PGD2 concentrations after 72 h of culture of 8 to 12 gestational week (GW) (A), 8–9.9 GW (B), and 10–12 GW (C) human fetal testes in the presence of the solvent DMSO (Control) or 10−7–10−4 M of ibuprofen. (D–F) PGE2 concentrations after 72 h of culture of 8–12 GW (D), 8–9.9 GW (E), and 10–12 GW (F) human fetal testes in the presence of DMSO (Control) or 10−7–10−4 M of ibuprofen. Results are expressed as fold change from the first day of culture (FC to D0) for both PGD2 and PGE2 productions. Data are means ± SEM (n = 4–10 testes from 4–10 fetuses for PGD2; n = 6−18 testes from 6–18 fetuses for PGE2). ANOVAs with a random embryo effect were performed using unstructured covariance matrices. A Wilcoxon test was performed for pairwise comparisons (*p < 0.05, **p < 0.01).
