Table 1 Summary of the endocrine-disrupting signatures of each tested analgesic ex vivo.
From: Ibuprofen results in alterations of human fetal testis development
Cell type | Hormone | Paracetamol | Ibuprofen | Aspirin | Indomethacin |
|---|---|---|---|---|---|
Leydig cell | Testosterone | ⇔ |
|
|
|
INSL3 |
|
| ⇔ | ⇔ | |
Sertoli cell | AMH | ⇔ |
|
| ⇔ |
Unknown | PGD2 | ⇔ | ⇔ | ⇔ | ⇔ |
PGE2 |
|
|
|
|
1
or 
2
- Data for paracetamol, aspirin and indomethacin come from26.
- 1After 24, 48 and 72 h of exposure.
- 2
In the 8–9.9 GW and 8–12 GW testes at 10−5 and 10−4M; 
in the 10–12 GW testes at 10−7 and 10−6M.
In the 8–9.9 GW and 8–12 GW testes at 10−5 and 10−4M; 
in the 10–12 GW testes at 10−7 and 10−6M.