Figure 1: Subcellular distribution of wild type and mutant tyrosinase and tyrosinase-like proteins in human melanocytes. | Scientific Reports

Figure 1: Subcellular distribution of wild type and mutant tyrosinase and tyrosinase-like proteins in human melanocytes.

From: Molecular outcomes, clinical consequences, and genetic diagnosis of Oculocutaneous Albinism in Pakistani population

Figure 1

eGFP-tagged TYR and TYRP1 wild type and mutant constructs (green) were transiently transfected in melanocytes grown at 37 °C. Calregulin (red) and DAPI (blue) were used as markers for the endoplasmic reticulum and nucleus, respectively. Merged images show the co-localization of only tyrosinase variants with calregulin, which indicated ER retention. The scale bar represents 20 μm for all panels.

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