Figure 2: Subcellular distribution of wild type and mutant OCA2 in HEK293 cells. | Scientific Reports

Figure 2: Subcellular distribution of wild type and mutant OCA2 in HEK293 cells.

From: Molecular outcomes, clinical consequences, and genetic diagnosis of Oculocutaneous Albinism in Pakistani population

Figure 2

eGFP-tagged OCA2 wild type and mutant constructs (green) were transiently transfected in HEK293 cells grown at 37 °C. Calregulin (red) and DAPI (blue) were used as markers for the endoplasmic reticulum and nucleus, respectively. Merged images show partial co-localization of OCA2 variants with calregulin, which indicated increased ER retention. The scale bar represents 20 μm for all panels.

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