Figure 4: The relationships among the lipophilicity, intracellular concentrations of individual statins, and their impact the gene expression change. | Scientific Reports

Figure 4: The relationships among the lipophilicity, intracellular concentrations of individual statins, and their impact the gene expression change.

From: Variability in statin-induced changes in gene expression profiles of pancreatic cancer

Figure 4

Statins were clustered according to their lipophilicity51 into 3 groups: hydrophilic (black color), lipophilic (red color), and highly lipophilic (green color). IC50 is expressed in μM, intracellular concentration (i.c.) of statins in nmol/100 000 cells, and gene expression change as log10(#DEG + 1).

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