Figure 5: Predicted functional association networks for all statins.
From: Variability in statin-induced changes in gene expression profiles of pancreatic cancer
Individual nodes represent drugs and genes products. Input nodes: atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. The action view of the statin association network was generated according to known and predicted interactions for Homo sapiens. Individual node colors indicate the type of the interaction: binding – blue ball, activation – green arrow, inhibition – red bar, catalysis – magenta ball, same activity - cyan, reaction – black ball. The line thickness indicates the confidence score. The complete description of the listed genes is stated in Suppl. Table 5.
